Article

Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion

2023-09-29

Abstract excerpt

Pancreatic β-cells are specialized for coupling glucose metabolism to insulin peptide production and secretion. Acute glucose exposure robustly and coordinately increases translation of proinsulin and proteins required for secretion of mature insulin peptide. By contrast, chronically elevated glucose levels that occur during diabetes impair β-cell insulin secretion and have been shown experimentally to suppress in...

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Literature Corpus work: 33d94982-1125-5793-9e74-faf949fca4a5
DOI: 10.1101/2023.09.29.560203

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