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The Downregulation of Type 1 Diabetes Susceptibility Gene PGM1 Induces Metabolic Imbalance and Stress in Pancreatic β-Cells.

Diabetes - 1 Jun 2026

Ye Jody, Qiu Yunping, Aguilan Jennifer T, Sun Yan, Kulkarni Rucha, Jankauskas Stanislovas S, Santulli Gaetano, Sidoli Simone, Kurland Irwin J, Tomer Yaron

Abstract excerpt

Phosphoglucomutase 1 (PGM1) is a type 1 diabetes susceptibility gene that potentially plays a key role in regulating central carbon metabolism in β-cells. Previous work suggested that β-cell PGM1 transcription is lowered after coxsackievirus B4 infection. Thus, we hypothesized that decreased PGM1 levels disrupt β-cell metabolic homeostasis and result in β-cell fragility and type 1 diabetes. First, we showed that...

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Identifiers

PMID: 41915415
DOI: 10.2337/db25-0191
PMCID: PMC13191401

Genes

PGM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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