Article
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.
Molecular cell - 24 Jun 2011
Lv Lei, Li Dong, Zhao Di, Lin Ruiting, Chu Yajing, Zhang Heng, Zha Zhengyu, Liu Ying, Li Zi, Xu Yanping, Wang Gang, Huang Yiran, Xiong Yue, Guan Kun-Liang, Lei Qun-Ying
Abstract excerpt
Most tumor cells take up more glucose than normal cells but metabolize glucose via glycolysis even in the presence of normal levels of oxygen, a phenomenon known as the Warburg effect. Tumor cells commonly express the embryonic M2 isoform of pyruvate kinase (PKM2) that may contribute to the metabolism shift from oxidative phosphorylation to aerobic glycolysis and tumorigenesis. Here we show that PKM2 is...
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