Article
Protein synthesis. The perks of balancing glucose.
Science (New York, N.Y.) - 3 Aug 2001
Sonenberg N, Newgard C B
Abstract excerpt
What do the regulation of translation initiation and glucose metabolism have to do with each other? Quite a lot, it seems, according to Sonenberg and Newgard in their Perspective. They discuss new findings that identify the kinase responsible for inactivating eIF2--a factor that is required for translation initiation (and hence protein synthesis)--when the endoplasmic reticulum is under stress. Loss of this...
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