Article

Collagen-inspired biomimetic peptides as therapeutic agents against methylglyoxal-mediated damage

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>Damage from increased levels of advanced glycation end-products (AGEs) is linked to aging and health problems such as diabetes, neurological disorders, and cardiovascular disease. Methylglyoxal (MG), a primary AGE precursor, is metabolized under normal conditions by the enzyme glyoxalase-1 (Glo1). However, in aging and disease, conditions including hypoxia, inflammation, ischemia, and o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5127e6c-adec-54ea-a42c-b98664ab2375
DOI: 10.21203/rs.3.rs-9509976/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Collagen-inspired biomimetic peptides as therapeutic agents against methylglyoxal-mediated damageDOI 10.21203/rs.3.rs-9509976/v1Read

Discovery of Glycation-Derived Crosslinks at ArginineSemantic proximity Read

Molecular Assessment of Methylglyoxal-Induced Toxicity and Therapeutic Approaches in Various Diseases: Exploring the Interplay with the Glyoxalase SystemSemantic proximity Read

Methylglyoxal in Cardiometabolic Disorders – Routes Leading to Pathology – Counterbalanced by Treatment StrategiesSemantic proximity Read

A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-ProductSemantic proximity Read

Novel Collagen Analogs with Multicopy Mucin-Type Sequences for Multifunctional Enhancement Properties Using SUMO Fusion TagsSemantic proximity Read

A designer mixture of six amino acids promotes the extracellular matrix gene expression in cultured human fibroblastsSemantic proximity Read

Methylglyoxal Induces Endothelial Dysfunction via Stunning-like PhenotypeSemantic proximity Read

Discovery of Diagnostic and Therapeutic Targets For Vascular Injury Induced By Methylglyoxal Using ProteomicsSemantic proximity Read

Glyoxal induces DNA-Protein Crosslinking in CellsSemantic proximity Read

Results supporting the concept of the oxidant-mediated protein amino acid conversion, a naturally occurring protein engineering process, in human cellsSemantic proximity Read

Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapySemantic proximity Read

Critical evaluation of toxic versus beneficial effects of methylglyoxalSemantic proximity Read