Back to search

Article

GEF Cytohesin-2/ARNO: a novel bridge between cell migration and immunoregulation in synovial fibroblasts

2021-10-05

Abstract excerpt

The guanine nucleotide exchange factor cytohesin-2 (ARNO) is a major activator of the small GTPase ARF6, and has been shown to play an important role(s) in cell adhesion, migration and cytoskeleton reorganization in various cell types and models of disease. Interestingly, dysregulated cell migration, in tandem with hyper-inflammatory responses, is one of the hallmarks associated with activated synovial fibroblasts...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
41e74648-388d-5912-b43d-0a68e420bf7d
DOI
10.1101/2021.10.04.463120
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
GEF Cytohesin-2/ARNO: a novel bridge between cell migration and immunoregulation in synovial fibroblastsDOI 10.1101/2021.10.04.463120
Diverse roles of guanine nucleotide exchange factors in regulating collective cell migrationSemantic proximity
RASAL3 regulates RAC/CDC42 GTPases, SAPK/JNK signaling, IL-2 gene activity, and directed motility in human T cellsSemantic proximity
Fibroblasts sense spatial proximity via an EGFR–CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritisSemantic proximity
GALNT1 drives aggressive phenotypes of rheumatoid synoviocytes via NEK9 O-glycosylation.Semantic proximity
Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferationSemantic proximity
Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration.Semantic proximity
Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.Semantic proximity
Dissecting the molecular control of immune cell accumulation in the inflamed jointSemantic proximity
The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2Semantic proximity
CYR61 synthesis is Induced by Interleukin-6 and Promotes Migration and Invasion of Fibroblast-like Synoviocytes in Rheumatoid ArthritisSemantic proximity
ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling.Semantic proximity
Role of Rho GTPases in stem cell regulationSemantic proximity
Select a neighboring publication to make it the new centre.