Article

Fibroblasts sense spatial proximity via an EGFR–CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritis

2025-12-12

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disease where the synovial lining membrane undergoes pathological changes resulting in joint destruction. In healthy joints, the synovial lining is essential for joint homeostasis, forming a selective barrier and secreting lubricating molecules, yet the mechanisms that restores homeostatic synovial lining during RA remission remains poorly understood. Here, we ap...

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Literature Corpus work: 7ae30f39-388b-59af-a77a-5ca0a87fb0b9
DOI: 10.64898/2025.12.10.693501

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