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Article

GALNT1 drives aggressive phenotypes of rheumatoid synoviocytes via NEK9 O-glycosylation.

JCI insight - 8 Jun 2026

Zou Yaoyao, Lin Haobo, Su Jianling, Wang Jieying, Zeng Qin, Feng Tianxiao, Lei Yunxia, Ma Jianda, Pan Hudan, Xu Hanshi, Dai Lie, Li Yang

Abstract excerpt

Fibroblast-like synoviocytes (FLSs) are crucial in driving synovial inflammation and joint damage in rheumatoid arthritis (RA). This study explored the functions and underlying mechanisms of GALNT1-mediated O-glycosylation, which is markedly upregulated in RA FLSs, in synovial aggression and subsequent experimental joint damage. Targeted suppression of GALNT1 effectively curtailed migration and invasion in RA...

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Topics

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Share to Arthritis, Experimental
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to N-Acetylgalactosaminyltransferases

Share to Polypeptide N-acetylgalactosaminyltransferase

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Source

Open in PubMed Open full text

Identifiers

PMID: 42024456
DOI: 10.1172/jci.insight.198245
PMCID: PMC13313538

Genes

GALNT1
NEK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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