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Article

Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation

9 Sept 2018

Abstract excerpt

Fibroblast-like synoviocytes (FLSs) are critical to synovial aggression and joint destruction in rheumatoid arthritis (RA). The role of long noncoding RNAs (lncRNAs) in RA is largely unknown. Here, we identified a lncRNA, LERFS (lowly expressed in rheumatoid fibroblast-like synoviocytes), that negatively regulates the migration, invasion, and proliferation of FLSs through interaction with heterogeneous nuclear...

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PMID: 30198906
DOI: 10.1172/jci97965

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