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Article

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.

Nature reviews. Rheumatology - 1 Jan 2013

Bottini Nunzio, Firestein Gary S

Abstract excerpt

Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component of this invasive synovium and have a major role in the initiation and perpetuation of destructive joint inflammation. The pathogenic potential of FLS in RA stems from their ability to express immunomodulating cytokines and...

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Identifiers

PMID: 23147896
DOI: 10.1038/nrrheum.2012.190
PMCID: PMC3970924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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