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Article

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration.

The Journal of cell biology - 5 Jun 2017

Zaritsky Assaf, Tseng Yun-Yu, Rabadán M Angeles, Krishna Shefali, Overholtzer Michael, Danuser Gaudenz, Hall Alan

Abstract excerpt

Efficient collective migration depends on a balance between contractility and cytoskeletal rearrangements, adhesion, and mechanical cell-cell communication, all controlled by GTPases of the RHO family. By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bronchial epithelial cell monolayers, we identified GEFs that are required for collective migration at large, such as SOS1 and...

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Source

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Identifiers

PMID: 28512143
DOI: 10.1083/jcb.201609095
PMCID: PMC5461017

Genes

RHOA
RHO
ARHGEF11
ARHGEF18
ARHGEF28
ARHGEF3
RHOC
SOS1

Provenance

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