Article

RASAL3 regulates RAC/CDC42 GTPases, SAPK/JNK signaling, IL-2 gene activity, and directed motility in human T cells

2026-07-27

Abstract excerpt

<h4>ABSTRACT</h4> RASAL3 acts as a negative regulator of small cellular GTPases in hematopoietic cells. In immune cells, it primarily modulates the RAS/MAPK signaling pathway and affects cellular events including proliferation, differentiation, survival, and migration. Due to its inhibitory role in T cells, RASAL3 may represent a potential modulatory target for improving therapeutic strategies such as cell-based...

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Literature Corpus work: ab20411b-71f7-596b-a994-fb4b0d1b833c
DOI: 10.64898/2026.07.24.740537

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