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RESP2: An uncertainty aware multi-target multi-property optimization AI pipeline for antibody discovery

2024-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Discovery of therapeutic antibodies against infectious disease pathogens presents distinct challenges. Ideal candidates must possess not only the properties required for any therapeutic antibody (e.g. specificity, low immunogenicity) but also high affinity to many mutants of the target antigen. Here we present RESP2, an enhanced version of our RESP pipeline, designed for the discovery of antibod...

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Literature Corpus work
41e71381-cead-5d92-be98-39135a174829
DOI
10.1101/2024.07.30.605700
Open publication

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RESP2: An uncertainty aware multi-target multi-property optimization AI pipeline for antibody discoveryDOI 10.1101/2024.07.30.605700
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