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RESP2: An Uncertainty Aware Multi‐Target Multi‐Property Optimization AI Pipeline for Antibody Discovery

4 Sept 2025

Abstract excerpt

Discovery of therapeutic antibodies against infectious disease pathogens presents distinct challenges. Ideal candidates must possess not only the properties required for any therapeutic antibody (e.g., specificity, low immunogenicity) but also high affinity to many mutants of the target antigen. Here, we present RESP2, an enhanced version of the Rapid Engineering System for Proteins (RESP) pipeline, designed for...

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PMID: 40908542
DOI: 10.1002/advs.202504350

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