Article

Enhancing Cardiac Reprogramming by Suppressing Specific C-C Chemokine Signaling Pathways

2019-01-16

Abstract excerpt

<h4>ABSTRACT</h4> Reprogramming fibroblasts into induced cardiomyocytes (iCMs) is a potentially promising strategy for heart regeneration. Yet a major challenge is the low conversion rate. To address this challenge, we screened and identified four chemicals, insulin-like growth factor-1, Mll1 inhibitor MM589, transforming growth factor-β inhibitor A83-01, and Bmi1 inhibitor PTC-209, termed as IMAP, that coordinat...

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Literature Corpus work: 3c8b5372-2ec5-5260-8b61-b828b3d8f789
DOI: 10.1101/522995

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