Article
Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells
2019-03-18
Abstract excerpt
<h4>Summary</h4> Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels 1-3 . At the chromatin level, aging is associated with the progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis 3 . The technology of nuclear reprogramming to p...
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Identifiers and source
- Literature Corpus work
- 8413d9f5-4d97-5f0c-8ea0-a50aa94a1f22
- DOI
- 10.1101/573386