Article

Resilience and Breakage in Proteomic Topological Structures: A Dynamic Analysis of Network Evolution Under Genomic Mutations

2024-08-21

Abstract excerpt

The intricate relationship between genomic mutations and proteomic network topology represents a frontier in understanding cellular resilience and disease mechanisms. This study presents a novel approach to analyzing how proteomic topological structures evolve and potentially break down in response to accumulating genomic mutations, offering insights into the complex interplay between genetic alterations and prote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41ca8282-112e-5e6d-bfb9-1f008f1c2296
DOI: 10.20944/preprints202408.1424.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resilience and Breakage in Proteomic Topological Structures: A Dynamic Analysis of Network Evolution Under Genomic MutationsDOI 10.20944/preprints202408.1424.v1Read

Mutation-induced biophysical destabilization as a key contributor to cancer-driving potential in the human structural protein interactomeSemantic proximity Read

Cancers adapt to their mutational load by buffering protein misfolding stress.Semantic proximity Read

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topologySemantic proximity Read

Crossed wires: 3D genome misfolding in human disease.Semantic proximity Read

Genome mutations and environmental perturbations reshape the epigenomic topology to drive functional collapse in digital cellsSemantic proximity Read

A stress response that allows highly mutated eukaryotic cells to survive and proliferateSemantic proximity Read

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology.Semantic proximity Read

Cancers adapt to their mutational load by buffering protein misfolding stressSemantic proximity Read

Genotype-phenotype relationships in light of a modular protein interaction landscape.Semantic proximity Read

A Systems-Level Structural Dependency Model of DNA Integrity: Operational Collapse as the Precursor to OncogenesisSemantic proximity Read

Adding levels of complexity enhances robustness and evolvability in a multilevel genotype-phenotype map.Semantic proximity Read

Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes.Semantic proximity Read