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Article

Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes.

Nature communications - 16 Jul 2020

Mehnert Martin, Ciuffa Rodolfo, Frommelt Fabian, Uliana Federico, van Drogen Audrey, Ruminski Kilian, Gstaiger Matthias, Aebersold Ruedi

Abstract excerpt

Rapidly increasing availability of genomic data and ensuing identification of disease associated mutations allows for an unbiased insight into genetic drivers of disease development. However, determination of molecular mechanisms by which individual genomic changes affect biochemical processes remains a major challenge. Here, we develop a multilayered proteomic workflow to explore how genetic lesions modulate the...

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Identifiers

PMID: 32678104
DOI: 10.1038/s41467-020-17387-y
PMCID: PMC7366679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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