Article

A Systems-Level Structural Dependency Model of DNA Integrity: Operational Collapse as the Precursor to Oncogenesis

2026-06-10

Abstract excerpt

<title>Abstract</title> <p>Biological systems maintain genomic integrity through three upstream structural environments: bioenergetic equilibrium, proteostasis capacity, and chromatin-based structural protection. These domains form a universal architecture required for accurate replication, repair, and long-term DNA stability. Within this framework, genetic mutations arise not as primary drivers of disease but as...

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Literature Corpus work: 6e500edd-0c1f-5f70-b8cc-e3df2cca60a6
DOI: 10.21203/rs.3.rs-9699982/v1

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