Article

Mutation-induced biophysical destabilization as a key contributor to cancer-driving potential in the human structural protein interactome

2026-04-19

Abstract excerpt

A systems-level investigation of mutation-induced perturbations in the human structural protein interactome, the network of structurally resolved protein–protein interactions in human cells, provides mechanistic insight into the complexity underlying oncogenesis. Mutations can destabilize protein folding or specific protein–protein interactions, resulting in loss-of-function effects within the interactome. Althoug...

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Literature Corpus work: 7ac90d59-2091-5ff9-b122-5afaa3b62c91
DOI: 10.64898/2026.04.15.718717

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