Crossed wires: 3D genome misfolding in human disease.

Abstract excerpt

Mammalian genomes are folded into unique topological structures that undergo precise spatiotemporal restructuring during healthy development. Here, we highlight recent advances in our understanding of how the genome folds inside the 3D nucleus and how these folding patterns are miswired during the onset and progression of mammalian disease states. We discuss potential mechanisms underlying the link among genome...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CCCTC-Binding Factor
• Share to Cell Nucleus
• Share to Chromosomes, Human