Article
Cancers adapt to their mutational load by buffering protein misfolding stress
2022-06-10
Abstract excerpt
In asexual populations that don’t undergo recombination, such as cancer, deleterious mutations are expected to accrue readily due to genome-wide linkage between mutations. Despite this mutational load of often thousands of deleterious mutations, many tumors thrive. How tumors survive the damaging consequences of this mutational load is not well understood. Here, we investigate the functional consequences of mutati...
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Identifiers and source
- Literature Corpus work
- 674d12e2-8fa7-56bb-bb7c-ce8f3b24046f
- DOI
- 10.1101/2022.06.08.495407