Article

Convergence of dispersed regulatory mutations predicts driver genes in prostate cancer

2016-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Cancer sequencing predicts driver genes using recurrent protein-altering mutations, but detecting recurrence for non-coding mutations remains unsolved. Here, we present a convergence framework for recurrence analysis of non-coding mutations using three-dimensional co-localization of epigenomically-identified regions. We define the regulatory plexus of each gene as its cell-type-specific three-di...

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Literature Corpus work: 41ca08ec-8da3-5e23-80a6-80e086a2711a
DOI: 10.1101/097451

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