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Article

Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms

15 Jul 2019

Abstract excerpt

Here we train cis-regulatory models of prostate tissue gene expression and impute expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer (PrCa) cases, 219,339 controls) from two large cohorts. Among 12,014 genes evaluated in the UK Biobank, we identify 38 associated with PrCa, many replicating in the Kaiser Permanente RPGEH. We report the association of elevated TMPRSS2 expression...

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PMID: 31308362
DOI: 10.1038/s41467-019-10808-7

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