Article
Convergent network effects along the axis of gene expression during prostate cancer progression.
Genome biology - 14 Dec 2020
Charmpi Konstantina, Guo Tiannan, Zhong Qing, Wagner Ulrich, Sun Rui, Toussaint Nora C, Fritz Christine E, Yuan Chunhui, Chen Hao, Rupp Niels J, Christiansen Ailsa, Rutishauser Dorothea, Rüschoff Jan H, Fankhauser Christian, Saba Karim, Poyet Cedric, Hermanns Thomas, Oehl Kathrin, Moore Ariane L, Beisel Christian, Calzone Laurence, Martignetti Loredana, Zhang Qiushi, Zhu Yi, Martínez María Rodríguez, Manica Matteo, Haffner Michael C, Aebersold Ruedi, Wild Peter J, Beyer Andreas
Abstract excerpt
BACKGROUND: Tumor-specific genomic aberrations are routinely determined by high-throughput genomic measurements. It remains unclear how complex genome alterations affect molecular networks through changing protein levels and consequently biochemical states of tumor tissues. RESULTS: Here, we investigate the propagation of genomic effects along the axis of gene expression during prostate cancer progression. We...
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