Article

<i>Cis</i> -regulatory Element Hijacking by Structural Variants Overshadows Higher-Order Topological Changes in Prostate Cancer

2021-01-06

Abstract excerpt

Prostate cancer is a heterogeneous disease whose progression is linked to genome instability. However the impact of this instability on the three-dimensional chromatin organization and how this drives progression is unclear. Using primary benign and tumour tissue, we find a high concordance in the higher-order three-dimensional genome organization across normal and prostate cancer cells. This concordance argues fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0c062c2-9de2-5052-8fe9-3736be6c42b7
DOI: 10.1101/2021.01.05.425333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Cis</i> -regulatory Element Hijacking by Structural Variants Overshadows Higher-Order Topological Changes in Prostate CancerDOI 10.1101/2021.01.05.425333Read

Chromatin remodeling restraints oncogenic functions in prostate cancerSemantic proximity Read

Decoding 3D chromatin architecture reveals distinct enhancer classes underlying hierarchical gene regulation in prostate cancerSemantic proximity Read

Patterns of Structural Variation Define Prostate Cancer Across Disease StatesSemantic proximity Read

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.Semantic proximity Read

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolutionSemantic proximity Read

Convergence of dispersed regulatory mutations predicts driver genes in prostate cancerSemantic proximity Read

Patterns of structural variation define prostate cancer across disease statesSemantic proximity Read

Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture.Semantic proximity Read

The genomic complexity of primary human prostate cancerSemantic proximity Read

Alterations in chromosome spatial compartmentalization classify prostate cancer progressionSemantic proximity Read

The Landscape of Prostate Tumour MethylationSemantic proximity Read

CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer.Semantic proximity Read