Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Network perturbation by recurrent regulatory variants in cancer.

PLoS computational biology - 1 Mar 2017

Jang Kiwon, Kim Kwoneel, Cho Ara, Lee Insuk, Choi Jung Kyoon

Abstract excerpt

Cancer driving genes have been identified as recurrently affected by variants that alter protein-coding sequences. However, a majority of cancer variants arise in noncoding regions, and some of them are thought to play a critical role through transcriptional perturbation. Here we identified putative transcriptional driver genes based on combinatorial variant recurrence in cis-regulatory regions. The identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Gene Expression Regulation, Neoplastic
Share to Genes, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Neoplasm Proteins

Share to Neoplasms

Share to Regulatory Elements, Transcriptional

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28333928
DOI: 10.1371/journal.pcbi.1005449
PMCID: PMC5383347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Network perturbation by recurrent regulatory variants in cancer.PMID 28333928Read ↗

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancersSemantic proximity Read ↗

Transcription Factor-Centric Approach to Identify Non-Recurring Putative Regulatory Drivers in CancerSemantic proximity Read ↗

Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations.Semantic proximity Read ↗

Disease-associated variants in different categories of disease located in distinct regulatory elements.Semantic proximity Read ↗

Predicting the recurrence of noncoding regulatory mutations in cancer.Semantic proximity Read ↗

Dissecting the sources of gene expression variation in a pan-cancer analysis identifies novel regulatory mutations.Semantic proximity Read ↗

Convergence of dispersed regulatory mutations predicts driver genes in prostate cancerSemantic proximity Read ↗

Pathway and network analysis of more than 2500 whole cancer genomes.Semantic proximity Read ↗

Candidate cancer driver mutations in superenhancers and long-range chromatin interaction networksSemantic proximity Read ↗

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers.Semantic proximity Read ↗

Recurrent somatic mutations in regulatory regions of human cancer genomes.Semantic proximity Read ↗

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.