Article

SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice

2022-12-07

Abstract excerpt

<title>Abstract</title> <p>Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2), associates with V617F mutation in Janus Activated Kinase 2 (JAK2) in some myeloproliferative neoplasms (MPNs), most commonly primary myelofibrosis. To explore <italic>Srsf2</italic><sup>P95H</sup> interaction with <italic>Jak2</italic><sup>V617F</sup>, we generated Cre-inducible knock-in mice e...

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Literature Corpus work: 41c6b0cc-4ccd-5d4a-80e4-555de857b3da
DOI: 10.21203/rs.3.rs-2338471/v1

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