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Article

Srsf2 P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

14 Jun 2018

Abstract excerpt

Key Points Srsf2 P95H/+ mutation within hemopoietic stem cells is required to initiate myeloid-biased hemopoiesis. Mutation of Srsf2 is sufficient to initiate the development of MDS/MPN in vivo in the setting of native hemopoiesis.

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Identifiers

PMID: 29903888
DOI: 10.1182/blood-2018-04-845602

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