SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.

doi:10.1038/s41375-023-01878-0

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Article

SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.

Leukemia - 1 Jun 2023

Willekens Christophe, Laplane Lucie, Dagher Tracy, Benlabiod Camelia, Papadopoulos Nicolas, Lacout Catherine, Rameau Philippe, Catelain Cyril, Alfaro Alexia, Edmond Valérie, Signolle Nicolas, Marchand Valentine, Droin Nathalie, Hoogenboezem Remco, Schneider Rebekka K, Penson Alex, Abdel-Wahab Omar, Giraudier Stephane, Pasquier Florence, Marty Caroline, Plo Isabelle, Villeval Jean-Luc, Constantinescu Stefan N, Porteu Françoise, Vainchenker William, Solary Eric

Abstract excerpt

Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2 (JAK2) in some myeloproliferative neoplasms (MPNs), most commonly primary myelofibrosis. To explore the interaction of Srsf2P95H with Jak2V617F, we generated Cre-inducible knock-in mice expressing these mutants under control of the stem cell leukemia (Scl) gene...

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PMID: 37100881
DOI: 10.1038/s41375-023-01878-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.PMID 37100881Read ↗

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