Article

Jak2 <sup>V617F</sup> Reversible Activation Shows an Essential Requirement for Jak2 <sup>V617F</sup> in Myeloproliferative Neoplasms

2022-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Janus kinases (JAKs) mediate cytokine signaling, cell growth and hematopoietic differentiation. 1 Gain-of-function mutations activating JAK2 signaling are seen in the majority of myeloproliferative neoplasm (MPN) patients, most commonly due to the JAK2 V617F driver allele. 2 While clinically-approved JAK inhibitors improve symptoms and outcomes in MPNs, remissions are rare, and mutant allele...

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Literature Corpus work: 11cc58ed-f51f-5789-862b-f5f730a99d8a
DOI: 10.1101/2022.05.18.492332

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