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Article

Mutant SRSF2-associated impaired erythropoiesis is defined by increased mTORC1 signaling due to FYN missplicing.

Leukemia - 1 Apr 2026

Jutzi Jonas S, Crosse Edie, Kim Chulwoo J, van Gasteren Bob, Laurore Charles, Rolles Benjamin, Kramer Frederike, Tishena Anastasia, Rocha Azucena V, Wazir Mohammed, Weeks Lachelle D, How Joan, Stahl Maximilian, Luskin Marlise R, Lindsley R Coleman, Pozdnyakova Olga, Rai Sumit, Graubert Timothy A, Bradley Robert K, Mullally Ann, Marneth Anna E

Abstract excerpt

Somatic mutations in RNA splicing regulators, including the serine/arginine-rich protein SRSF2, are frequently observed in myeloid malignancies. Using mouse models and primary human samples, we investigated the impact of SRSF2 mutations on erythropoiesis. We found reduced erythropoiesis in Srsf2P95H versus wild-type mice upon stress-induced erythropoiesis and identified that SRSF2 mutations correlate with reduced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41748695
DOI: 10.1038/s41375-026-02892-8

Genes

SRSF2
FYN
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Mutant SRSF2-associated impaired erythropoiesis is defined by increased mTORC1 signaling due to FYN missplicing.PMID 41748695Read ↗

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