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Article

SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.

Blood cancer journal - 27 Nov 2023

Yang Yue, Abbas Salar, Sayem Mohammad A, Dutta Avik, Mohi Golam

Abstract excerpt

SRSF2 mutations are found in association with JAK2V617F in myeloproliferative neoplasms (MPN), most frequently in myelofibrosis (MF). However, the contribution of SRSF2 mutation in JAK2V617F-driven MPN remains elusive. To investigate the consequences of SRSF2P95H and JAK2V617F mutations in MPN, we generated Cre-inducible Srsf2P95H/+Jak2V617F/+ knock-in mice. We show that co-expression of Srsf2P95H mutant reduced...

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Identifiers

PMID: 38012156
DOI: 10.1038/s41408-023-00947-y
PMCID: PMC10682023

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SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.PMID 38012156Read ↗

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