Article
Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms.
Leukemia - 1 Oct 2022
Wang Borwyn A, Mehta Hrishikesh M, Penumutchu Srinivasa R, Tolbert Blanton S, Cheng Chonghui, Kimmel Marek, Haferlach Torsten, Maciejewski Jaroslaw P, Corey Seth J
Abstract excerpt
Alternatively spliced colony stimulating factor 3 receptor (CSF3R) isoforms Class III and Class IV are observed in myelodysplastic syndromes (MDS), but their roles in disease remain unclear. We report that the MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis. Add-back of the Class IV isoform in Csf3r-null mouse progenitor cells increased...
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