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Article

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.

Molecular and cellular biology - 1 Sept 2015

Komeno Yukiko, Huang Yi-Jou, Qiu Jinsong, Lin Leo, Xu YiJun, Zhou Yu, Chen Liang, Monterroza Dora D, Li Hairi, DeKelver Russell C, Yan Ming, Fu Xiang-Dong, Zhang Dong-Er

Abstract excerpt

Myelodysplastic syndromes (MDS) are a group of neoplasms characterized by ineffective myeloid hematopoiesis and various risks for leukemia. SRSF2, a member of the serine/arginine-rich (SR) family of splicing factors, is one of the mutation targets associated with poor survival in patients suffering from myelodysplastic syndromes. Here we report the biological function of SRSF2 in hematopoiesis by using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26124281
DOI: 10.1128/MCB.00202-15
PMCID: PMC4525309

Genes

SRSF2

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SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.PMID 26124281Read ↗

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