Article

Distinct and cooperative roles of host and tumor Osteopontin in colorectal cancer liver metastasis

2026-02-20

Abstract excerpt

<h4>Summary</h4> Osteopontin (OPN) is a secreted phosphoprotein implicated in colorectal cancer liver metastasis (CRCLM), yet the distinct spatial contributions of host-and tumor-derived OPN in driving this disease remain unclear. Using a 2 x 2 genetic knockout mouse model targeting OPN in host and tumor compartments, combined with spatial transcriptomics, we investigated compartment-specific OPN functions in CRC...

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Literature Corpus work: 41c62c51-fe92-598b-9f32-6446ae0a90c1
DOI: 10.64898/2026.02.19.706899

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