Article
Role of osteopontin in cellular signaling and metastatic phenotype.
Frontiers in bioscience : a journal and virtual library - 1 May 2008
El-Tanani Mohamed K
Abstract excerpt
Osteopontin (opn) is a glyco-phosphoprotein that is expressed and secreted by numerous human cancers. Opn has pivotal role in cell adhesion, chemotaxis, prevention of apoptosis, invasion, migration and anchorage-independent growth of tumor cells. Extensive research has demonstrated the pivotal role of opn in regulation of cellular signaling, which controls neoplastic and malignant transformation. The elevated...
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