Article
Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases.
Gastroenterology - 1 Dec 2024
Zhao Joseph J, Ong Chin-Ann Johnny, Srivastava Supriya, Chia Daryl Kai Ann, Ma Haoran, Huang Kiekyon, Sheng Taotao, Ramnarayanan Kalpana, Ong Xuewen, Tay Su Ting, Hagihara Takeshi, Tan Angie Lay Keng, Teo Melissa Ching Ching, Tan Qiu Xuan, Ng Gillian, Tan Joey Wee-Shan, Ng Matthew Chau Hsien, Gwee Yong Xiang, Walsh Robert, Law Jia Hao, Shabbir Asim, Kim Guowei, Tay Yvonne, Her Zhisheng, Leoncini Giuseppe, Teh Bin Tean, Hong Jing Han, Tay Ryan Yong Kiat, Teo Chong Boon, Dings Mark P G, Bijlsma Maarten, Lum Jeffrey Huey Yew, Mathur Sachin, Pietrantonio Filippo, Blum Steven M, van Laarhoven Hanneke, Klempner Samuel J, Yong Wei Peng, So Jimmy Bok Yan, Chen Qingfeng, Tan Patrick, Sundar Raghav
Abstract excerpt
BACKGROUND & AIMS: Peritoneal metastasis (PM) in gastric cancer (GC) is associated with poor prognosis and significant morbidity. We sought to understand the genomic, transcriptomic, and tumor microenvironment (TME) features that contribute to peritoneal organotropism in GC. METHODS: We conducted a comprehensive multi-omic analysis of 548 samples from 326 patients, including primary tumors, matched normal...
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