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Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

30 Nov 2023

Abstract excerpt

The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the complexity of the in vivo microenvironment. Here we predict cancer-TME interactions from single cell transcriptomic maps of both human colorectal cancers (CRCs) and mouse CRC models, ask how these interactions...

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PMID: 38036590
DOI: 10.1038/s41467-023-43746-6

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