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Phenotypic heterogeneity and plasticity in colorectal cancer metastasis

19 May 2025

Abstract excerpt

Phenotypic heterogeneity and plasticity in colorectal cancer (CRC) has a crucial role in tumor progression, metastasis, and therapy resistance. However, the regulatory factors and the extrinsic signals driving phenotypic heterogeneity remain unknown. Using a combination of single-cell multiomics and spatial transcriptomics data from primary and metastatic CRC patients, we reveal cancer cell states with...

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PMID: 40393458
DOI: 10.1016/j.xgen.2025.100881

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