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Article

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

PLoS genetics - 1 Mar 2018

Senchuk Megan M, Dues Dylan J, Schaar Claire E, Johnson Benjamin K, Madaj Zachary B, Bowman Megan J, Winn Mary E, Van Raamsdonk Jeremy M

Abstract excerpt

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple species including worms, flies and mice. Here, we study three C. elegans mitochondrial mutants (clk-1, isp-1 and nuo-6) to identify overlapping genetic pathways that contribute to their longevity. We find that genes regulated by the FOXO transcription factor DAF-16 are upregulated in all three strains, and that the...

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Identifiers

PMID: 29522556
DOI: 10.1371/journal.pgen.1007268
PMCID: PMC5862515

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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