Article

Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of drug response and malignancy

2020-01-14

Abstract excerpt

<h4>Background</h4> Glioblastoma is a deadly brain tumor with median patient survival of 14.6 months. At the core of this malignancy are rare, highly heterogenous malignant stem-like tumor initiating cells. Aberrant signaling across the EGFR-PTEN-AKT-mTOR signal transduction pathways are common oncogenic drivers in these cells. Though gene-level clustering has determined the importance of the EGFR signaling pathw...

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Literature Corpus work: 418895da-f86b-5e1c-b8ac-91d7420bc1cc
DOI: 10.1101/2020.01.14.900506

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