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Defining phenotypic and functional heterogeneity of glioblastoma stem cells by mass cytometry

5 Jan 2021

Abstract excerpt

Most patients with glioblastoma (GBM) die within 2 years. A major therapeutic goal is to target GBM stem cells (GSCs), a subpopulation of cells that contribute to treatment resistance and recurrence. Since their discovery in 2003, GSCs have been isolated using single-surface markers, such as CD15, CD44, CD133, and α6 integrin. It remains unknown how these single-surface marker-defined GSC populations compare with...

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PMID: 33400685
DOI: 10.1172/jci.insight.128456

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