Article

Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneity

2025-01-13

Abstract excerpt

The intra- and inter-tumoral heterogeneity of glioblastoma represents a significant therapeutic challenge, as well as difficulty in generating reliable models for in vitro studies. Historical 2D adherent cell lines do not recapitulate this complexity, whereas both patient-derived neurospheres (PDN) and organoids (PDO) demonstrate intra-tumoral heterogeneity. Here, we quantify the tumor cell composition from match...

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Literature Corpus work: 7d49cc78-d72c-5ae2-b52a-9dc191b7121e
DOI: 10.1101/2025.01.08.632025

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