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Article

Single-Cell Profiling and Proteomics-Based Insights Into mTORC1-Mediated Angio+TAMs Polarization in Recurrent IDH-Mutant Gliomas.

CNS neuroscience & therapeutics - 1 Apr 2025

Wang Xu, Gu Jingyan, Tang Hongyu, Gu Lianping, Bi Yunke, Kong Yue, Shan Qiao, Yin Jian, Lou Meiqing, Li Shouwei, Liu Yaohua

Abstract excerpt

BACKGROUND: IDH mutant gliomas often exhibit recurrence and progression, with the mTORC1 pathway and tumor-associated macrophages potentially contributing to these processes. However, the precise mechanisms are not fully understood. This study seeks to investigate these relationships using proteomic, phosphoproteomic, and multi-dimensional transcriptomic approaches. METHODS: This study established a matched...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40202138
DOI: 10.1111/cns.70371
PMCID: PMC11979715

Genes

AURKA
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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