Article
Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma.
Stem cells (Dayton, Ohio) - 1 Jun 2016
Rennert Robert C, Achrol Achal S, Januszyk Michael, Kahn Suzana A, Liu Tiffany T, Liu Yi, Sahoo Debashis, Rodrigues Melanie, Maan Zeshaan N, Wong Victor W, Cheshier Samuel H, Chang Steven D, Steinberg Gary K, Harsh Griffith R, Gurtner Geoffrey C
Abstract excerpt
Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC...
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