Article

The geometry of <i>G</i> × <i>E</i> : how scaling and endogenous treatment effects shape interaction direction

2025-07-18

Abstract excerpt

Gene-environment interaction ( G × E ) studies hold promise for identifying genetic loci mediating the effects of environmental risk on disease. However, interpretation of G × E effects is often confounded by two fundamental issues: the dependence of interaction estimates on outcome scale and the presence of endogenous treatment effects, in which genetic liability influences environmental exposure. These facto...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 417a7ab0-f11f-5696-964c-27b8c335d7b0
DOI: 10.1101/2025.07.15.664999

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest

The geometry of <i>G</i> × <i>E</i> : how scaling and endogenous treatment effects shape interaction directionDOI 10.1101/2025.07.15.664999Read

The geometry of G × E: How scaling and endogenous treatment effects shape interaction direction.Semantic proximity Read

Choice of phenotype scale is critical in biobank-based G×E testsSemantic proximity Read

DetectGxT: detecting gene-by-treatment interactions on molecular count phenotypes accounting for allelic additivitySemantic proximity Read

Modeling Interaction and Dispersion Effects in the Analysis of Gene-by-Environment Interaction.Semantic proximity Read

Probabilistic classification of gene-by-treatment interactions on molecular count phenotypesSemantic proximity Read

Varying coefficient model for gene-environment interaction: a non-linear look.Semantic proximity Read

Screening for interaction effects in gene expression data.Semantic proximity Read

Joint effect of genes and environment distorted by selection biases: implications for hospital-based case-control studies.Semantic proximity Read

A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator.Semantic proximity Read

Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies.Semantic proximity Read