Article

DetectGxT: detecting gene-by-treatment interactions on molecular count phenotypes accounting for allelic additivity

2026-08-05

Abstract excerpt

<h4>Motivation</h4> Identifying the mechanisms by which genetic variants affect the molecular response to an applied treatment is important across multiple biological fields, and an effective approach to this end is interaction molecular QTL mapping. However, the statistical models commonly used to detect such gene-by-treatment interactions (G×T) are non-trivially misspecified, and this can lead to decreased powe...

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Literature Corpus work: 403d176e-9337-51a5-a35c-5cb48d555ae9
DOI: 10.64898/2026.07.30.740713

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