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Article

A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator.

American journal of epidemiology - 1 Sept 2021

Sanyal Nilotpal, Napolioni Valerio, de Rochemonteix Matthieu, Belloy Michaël E, Caporaso Neil E, Landi Maria Teresa, Greicius Michael D, Chatterjee Nilanjan, Han Summer S

Abstract excerpt

Evaluating gene by environment (G × E) interaction under an additive risk model (i.e., additive interaction) has gained wider attention. Recently, statistical tests have been proposed for detecting additive interaction, utilizing an assumption on gene-environment (G-E) independence to boost power, that do not rely on restrictive genetic models such as dominant or recessive models. However, a major limitation of...

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Identifiers

PMID: 33942053
DOI: 10.1093/aje/kwab124
PMCID: PMC8579053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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