Patterns of ANA+ B cells for SLE patient stratification

doi:10.1172/jci.insight.127885

Article

Patterns of ANA+ B cells for SLE patient stratification

1 May 2019

Abstract excerpt

IgG antinuclear antibodies (ANAs) are a dominant feature of several autoimmune diseases. We previously showed that systemic lupus erythematosus (SLE) is characterized by increased ANA+ IgG plasmablasts/plasma cells (PCs) through aberrant IgG PC differentiation rather than an antigen-specific tolerance defect. Here, we aimed to understand the differentiation pathways resulting in ANA+ IgG PCs in SLE patients. We...

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